Browsing by Author "Cevik, Ozge"
Now showing items 1-20 of 32
-
Ameliorative effects of riboflavin on acetic acid-induced colonic injury in rats
Karakoyun, Berna; Ertas, Busra; Yuksel, Meral; Akakin, Dilek; Cevik, Ozge; Sener, Goksel (WILEY, 2018)Riboflavin (RF) has been found to be a promising antioxidant and/or anti-inflammatory agent in several studies. However, the effect of RF against acetic acid (AA)-induced colonic injury is currently unknown. This study ... -
Antioxidant Agent Quercetin Prevents Impairment of Bladder Tissue Contractility and Apoptosis in a Rat Model of Ischemia/Reperfusion Injury
Tinay, Ilker; Sener, Tarik E.; Cevik, Ozge; Cadirci, Selin; Toklu, Hale; Cetinel, Sule; Sener, Goeksel; Tarcan, Tufan (WILEY, 2017)ObjectivesTo examine the possible protective effect of quercetin (QT), which is well known for its antioxidant and protective effects in circumstances of oxidative stress, on urinary bladder tissue in a rat model of ... -
The apoptotic actions of platelets in acute ischemic stroke
Cevik, Ozge; Adiguzel, Zelal; Baykal, Ahmet Tarik; Somay, Goksel; Sener, Azize (SPRINGER, 2013)Stroke is a disease that affects the blood vessels that supply blood to the brain. Although platelets are implicated in the pathophysiology of stroke the mechanism is still not clear and there antiplatelet agents available ... -
Beneficial effects of quercetin on rat urinary bladder after spinal cord injury
Cevik, Ozge; Ersahim, Mehmet; Sener, T. Emre; Tinay, Ilker; Tarcan, Tufan; Cetinel, Sule; Sener, Azize; Toklu, Hale Z.; Sener, Goksel (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2013)Background: Spinal cord injury (SCI) leads to an inflammatory response and generates oxidative stress, which has deleterious effects on the function of several organ systems, including the urinary bladder. The present study ... -
Cyclosporine-A induces apoptosis in human prostate cancer cells PC3 and DU145 via downregulation of COX-2 and upregulation of TGF beta
Cevik, Ozge; Turut, Fatma Aysun; Acidereli, Hilal; Yildirim, Sahin (WALTER DE GRUYTER GMBH, 2019)Background: Potential targets for prostate cancer therapy are urgently needed for curative of patients. Cyclosporine-A (CsA), an immunosuppressive and a selective cyclooxygenase-2 (COX-2) inhibitor, exerts antitumor activity. ... -
The effect of Momordica charantia intake on the estrogen receptors ESR alpha/ESR beta gene levels and apoptosis on uterine tissue in ovariectomy rats
Cevik, Ozge; Akpinar, Hikmet; Oba, Rabia; Cilingir, Ozlem Tugce; Ozdemir, Zarife Nigar; Cetinel, Sule; Yoldemir, Tevfik (SPRINGER, 2015)Estrogen or combinational hormone therapy can protect to menopausal symptoms but exogenous estrogen therapy has some potential risks which in turns lead to the appearance of various diseases. In recent years plants with ... -
The effect of topical ethanol extract of Cotinus coggygria Scop. on cutaneous wound healing in rats
Aksoy, Halil; Sancar, Mesut; Sen, Ali; Okuyan, Betul; Bitis, Leyla; Uras, Fikriye; Akakin, Dilek; Cevik, Ozge; Kultur, Sukran; Izzettin, Fikret Vehbi (TAYLOR & FRANCIS LTD, 2016)The aim of this study is to determine the cutaneous wound healing effects of the ethanol extract of Cotinus coggygria leaves in rats by excision wound model to provide scientific evidence for the traditional use of C. ... -
Effects of Alendronate on Kidney Tissue of Ovariectomized Rats
Cevik, Ozge; Arslan, Ahmet Hamdi (KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2013)Alendronate is an aminophosphanate, selective inhibitory of bone resorbtion, used for treatment of osteoporosis in postmenopause. It is known that changes occurring in postmenopausal period effect the quality of life. In ... -
The Effects of Melatonin on Ethylene Glycol-induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression
Sener, Tarik Emre; Sener, Goksel; Cevik, Ozge; Eker, Pinar; Cetinel, Sule; Traxer, Olivier; Tanidir, Yiloren; Akbal, Cem (ELSEVIER SCIENCE INC, 2017)OBJECTIVE To evaluate the protective effects of melatonin (Mel) on an ethylene glycol (EG)-induced nephrolithiasis model in rats. MATERIALS AND METHODS Thirty-two Wistar albino rats were divided into 4 groups: control, EG, ... -
Effects of Myrtus communis extract treatment in bile duct ligated rats
Sen, Ali; Ozkan, Sevil; Recebova, Kafiye; Cevik, Ozge; Ercan, Feriha; Demirci, Elif Kervancioglu; Bitis, Leyla; Sener, Goksel (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016)Background: The aim of our study was to investigate the antifibrotic and antioxidant effects of Myrtus communis subsp. communis (MC) extract against liver injury and fibrosis occurring in rats with biliary obstruction. ... -
The effects of topical melatonin on oxidative stress, apoptosis signals, and p53 protein expression during cutaneous wound healing
Sener, Azize; Cevik, Ozge; Dogan, Ozge; Altindis, Nazli Gul; Aksoy, Halil; Okuyan, Betul (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2015)Elimination of reactive oxygen species (ROS) can be an important strategy to improve healing of wounds. ROS have an effect on proliferation and cell survival signaling, which results in alteration of apoptotic pathways in ... -
Etanercept protects myocutaneous flaps from ischaemia reperfusion injury: An experimental study in a rat tram flap model
Ersoy, Burak; Cevik, Ozge; Cilingir, Ozlem Tugce (TAYLOR & FRANCIS LTD, 2016)Background Being an inevitable component of free tissue transfer, ischemia-reperfusion injury tends to contribute to flap failure. TNF- is an important proinflammatory cytokine and a prominent mediator of the ischemia-reperfusion ... -
Increased Betatrophin and WISP1 Levels in Gestational Diabetes
Ersoy, Gulcin Sahin; Ensari, Tugba Altun; Cevik, Ozge (SAGE PUBLICATIONS INC, 2016)… -
Interferon regulatory factor 5 (IRF5) suppresses hepatitis C virus (HCV) replication and HCV-associated hepatocellular carcinoma
Cevik, Ozge; Li, Dan; Baljinnyam, Erdene; Manvar, Dinesh; Pimenta, Erica M.; Waris, Gulam; Barnes, Betsy J.; Kaushik-Basu, Neerja (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017)Hepatitis C virus (HCV) infection is a major risk factor for the development of chronic liver disease. The disease typically progresses from chronic HCV to fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and death. ... -
Investigation into the role of the cholinergic system in radiation-induced damage in the rat liver and ileum
Ozyurt, Hazan; Ozden, A. Sevgi; Cevik, Ozge; Ozgen, Zerrin; Cadirci, Selin; Elmas, Merve Acikel; Ercan, Feriha; Sener, Goksel; Goren, M. Z. (OXFORD UNIV PRESS, 2014)It has been previously shown that acetylcholine (ACh) may affect pro-inflammatory and anti-inflammatory cytokines. The role of the cholinergic system in radiation-induced inflammatory responses and tissue damage remains ... -
Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer
Dastan, Taner; Kocyigit, Umit M.; Dastan, Sevgi Durna; Kilickaya, Pakize Canturk; Taslimi, Parham; Cevik, Ozge; Koparir, Metin; Orek, Cahit; Gulcin, Ilhami; Cetin, Ahmet (WILEY, 2017)The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel ... -
Melatonin and tadalafil treatment improves erectile dysfunction after spinal cord injury in rats
Tavukcu, Hasan Huseyin; Sener, Tarik Emre; Tinay, Ilker; Akbal, Cem; Ersahin, Mehmet; Cevik, Ozge; Cadirci, Selin; Reiter, Russel J.; Sener, Goksel (WILEY, 2014)Oxidative stress plays an important role both in spinal cord injury (SCI) and erectile dysfunction (ED). The present study investigated the effects of melatonin and tadalafil treatment alone or in combination on SCI-induced ... -
Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury
Ersahin, Mehmet; Cevik, Ozge; Akakin, Dilek; Sener, Azize; Ozbay, Latif; Yegen, Berrak C.; Sener, Goksel (ELSEVIER SCIENCE INC, 2012)Spinal cord injury (SCI) leads to an inflammatory response that generates substantial secondary damage within the tissue besides the primary damage. Leukotrienes are biologically active 5-lipoxygenase products of arachidonic ... -
Mycophenolate mofetil attenuates uterine ischaemia/reperfusion injury in a rat model
Ersoy, Gulcin Sahin; Eken, Meryem Kurek; Cevik, Ozge; Cilingir, Ozlem T.; Tal, Reshef (ELSEVIER SCI LTD, 2017)This study evaluated the effect of mycophenolate mofetil (MMF) on uterine tissue preservation following ischaemia/reperfusion (I/R) injury. Uterine I/R injury was induced in rats by clamping the lower abdominal aorta and ...